Zare-Eelanjegh, Elaheh
Dep. Inf.techno.u.Elektrotechnik
Gloriastrasse 37/ 39
8092
Zürich
Switzerland
Open Master Thesis project: Unveiling Nucleus Elasticity In Situ with Dual Control System
In this full time master project, we delve into the intricate world of cell nuclei as pivotal intracellular mechanosensors and mechanotransducers. Traditional methods for in situ nucleus elasticity measurement often demand elaborate hardware setups and intensive computational analysis. Our pioneering approach combines a FluidFM injection system with simultaneous fluorescent video recording during force spectroscopy, enhancing both spatial resolution and cellular event preservation. By meticulously correlating indentation events with nucleus membrane rupture, we accurately pinpoint serial contact points within force curves. The essence of our study lies in data analysis and image processing, enabling us to unravel the nuanced variations in elastic modulus between the nucleus and the cytoplasm.
You have...
- Strong motivation and background in Bioengineering field
- Creativity and independent working experiences
- Experiences in data analysis with Python and/or MATLAB
- Experiences in cell culture
For more details please contact Elaheh ZARE at
You are encouraged to include your background, interest, and some information about yourself in your email.
Research Interest
I. Injection of engineered biomolecules and nanoparticles into the single primary cells for Precision Medicine
II. Intracellular and nuclear extraction of biomolecules for single cell metabolomics and transcriptomics
Education
M.Sc. in Materials Science & Minor in Biomedical Engineering, EPFL, Switzerland
Exchange Master Thesis at Harvard-MIT Division of Health Science and Technology, Harvard Medical School, Boston, MA, US
