Schlotter, Til

Til Schlotter

PhD student, Jan. 2018 to March 2023

Research interests

- Transport of biopolymers (DNA, proteins) across nanostructures
- (Molecular) Sensing of biopolymers on single cell level
- Micro- and nanofabrication
- Microfluidics and electrophysiology

Education

- M.Sc. Mechanical Engineering, ETH Zurich, Switzerland
- Master Thesis at the University of British Columbia, Canada
- B.Sc. Mechanical Engineering, ETH Zurich, Switzerland

Student projects

Feel free to cantact me in case you are interested in a project about nanopore / AFM sensing of biomolecules, data analysis, or microfabrication of different substrates. Please also include your CV, a current overview of your courses (e.g. mystudies), and 2-3 sentences about your skills / experiences.

Student projects will be defined individually but might cover one of the following topics:

- Electro-chemical experiments and data analysis of single biomolecules
- Design and fabrication of Si-chips with nanostructures for micro-/nano-fluidics and electro-chemical readout
- Design and programming of a software to control and analyze a single biomolecule sensing setup (LabVIEW and/or Python)
- Microfluidic/electrochemical simulations (COMSOL)

Selected publications

external pageForce-Controlled Formation of Dynamic Nanopores for Single-Biomolecule Sensing and Single-Cell Secretomics
T. Schlotter, S. Weaver, C. Forró, D. Momotenko, J. Vörös, T. Zambelli, and M. Aramesh
ACS Nano, 2020 DOI: 10.1021/acsnano.0c04281

external pageLocalized detection of ions and biomolecules with a force-controlled scanning nanopore microscope
M Aramesh, C Forró, L Dorwling-Carter, I Lüchtefeld, T Schlotter, SJ Ihle, I Shorubalko, V Hosseini, D Momotenko, T Zambelli, E Klotzsch, J Vörös
Nature Nanotechnology, 2019, DOI: 10.1038/s41565-019-0493-z

Oral presentations

"Interface Nanopores as a Flexible Technology for Next-Generation Single-Molecule Protein Sensing"
T. Schlotter, T. Kloter, N. Nakatsuka,M. Aramesh, J. Vörös, T. Zambelli
66th Biophysical Society Annual Meeting, 19-23 February 2022, San Francisco, USA

"AFM-Controlled Interface Nanopores for Single Biomolecule Sensing and Neuron Secretion Analysis"
T. Schlotter, T. Kloter, S. Weaver, N. Nakatsuka, D. Momotenko, M. Aramesh, J. Vörös, T. Zambelli
NanoBioTech, 15-17 November 2021, Montreux, Switzerland

"Force-Controlled Interface Nanopores for Single-Molecule and Single-Cell Secretion Sensing"
T. Schlotter, T. Kloter, S. Weaver, N. Nakatsuka, D. Momotenko, M. Aramesh, J. Vörös, T. Zambelli
13th European Biophysics Conference, 24-28 July 2021, Vienna, Austria

"Cell Secretion Measurements using Force-Controlled Interface Nanopores"
T. Schlotter, T. Kloter, S. Weaver, D. Momotenko, M. Aramesh, J. Vörös, T. Zambelli, N. Nakatsuka
European Biosensor Symposium, 9-12 March 2021, online

"Single-Molecule Sensing of Cell Secretion using Force-Controlled Nanopores"
T. Schlotter, S. Weaver, D. Momotenko, J. Vörös, T. Zambelli, M. Aramesh
Single-Molecule Sensors and nanoSystems International Conference (S3IC), 9-11 November 2020, online (planned: Barcelona), Spain
This presentation won the prize for the best oral presentation of S3IC 2020

external page"Force-controlled nanopores for single cell measurements using micro-channeled AFM cantilevers"
T. Schlotter, S. Weaver, J. Vörös, T. Zambelli, M. Aramesh
The Biophysical Society Annual Meeting (BPS), 15-19 February 2020, San Diego , USA
Biophysical Journal , 2020, 118.3: 174a.

"Formation of force-controlled nanopores for protein sensing using micro-channeled afm cantilevers"
T. Schlotter, J. Vörös, T. Zambelli, M. Aramesh
Single Molecule Protein Sequencing (SMPS) conference, 16-19 September 2019, Jerusalem, Israel

Poster presentations

"Amino acid-specific detection of peptides using aptamer-functionalized interface nanopores"
T. Schlotter, T. Kloter, N. Nakatsuka, J. Vörös, T. Zambelli
Swiss Nanoconvention, 5-6 July, Fribourg, Switzerland

"Using aptamer-functionalized interface nanopores for amino acid-specific peptide sensing"
T. Schlotter, T. Kloter, J. Hengsteler, N. Nakatsuka, J. Vörös, T. Zambelli
From Solid State To Biophysics X , 11-18 June 2022, Dubrovnik, Croatia

"Integrating a nanopore into a micro-channeled AFM cantilever for the localized detection of ions and biomolecules"
T. Schlotter, S. Weaver, C. Forró, I. Lüchtefeld, I. Shorubalko, D. Momotenko, E. Klotzsch, J. Vörös, T. Zambelli, M. Aramesh
The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), 27-31 October 2019, Basel, Switzerland

"Slowdown and detection of nanoparticles and biomolecules using an AFM controlled, cantilever embedded nanopore"
T. Schlotter, J. Vörös, T. Zambelli, M. Aramesh
European Biophysics Congress (EBSA), 20-24 July 2019, Madrid, Spain
This poster won the Best Poster Award

"Detection of individual nanoparticle and biopolymer translocations with a micro-channelled cantilever"
T. Schlotter, J. Vörös, T. Zambelli, M. Aramesh
Single-Molecule Sensors and NanoSystems International Conference (S3IC), 3-5 April 2019, Munich, Germany

"On demand confinement of DNA using an AFM setup with a micro-channelled cantilever"
T. Schlotter, J. Vörös, M. Aramesh
Biointerfaces International, 2018 August 14 - 16, Zurich, Switzerland
This poster won the Best Poster Award

"DNA translocation measurements using a modified scanning ion-conductance nanopore setup"
T. Schlotter, J. Vörös, M. Aramesh
From Solid State To Biophysics IX, 2018 June 16 - 22, Dubrovnik, Croatia
This poster won the Best Poster Award