Student Projects
Here is a list of some of our actual student projects. However, note that we are also accustomed to tailor the project on the expertise and interests of each student. If you are interested in learning more you can contact the project responsibles or Janos Vörös..
Assembling an advanced high-speed SICM for live cell imaging
Scanning ion conductance microscopy (SICM) is the non-contact SPM technology to image live cells based on glass capillaries with a nanometric aperture. It applies a voltage and measures the ionic current flowing through the pipette above the sample in the buffer solution: the recorded current represents the feedback signal to measure the topography of the sample. In collaboration with Prof. Fantner at EPFL, this project aims to assemble a state of the art high-speed SICM to enable time-resolved live cell imaging.
Keywords
high-speed SICM, live cell imaging, control, electronics, FPGA, and data analysis
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Course Project , Lab Practice , Bachelor Thesis , Master Thesis , ETH Zurich (ETHZ) , Summer School
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Published since: 2024-05-03 , Earliest start: 2024-01-08
Organization Biosensors and Bioelectronics (LBB)
Hosts Xu Mengjia
Topics Information, Computing and Communication Sciences , Engineering and Technology
FluidFM-based nanoscale printing for wearable self-powering biomedical real time sensing
What about implantable self-powering devices to monitor biophysical signals at nanoscale? As a part of the interdisciplinary frontier between material science and new biomedical applications, being able to monitor biological or physical markers and signals, allows for a better treatment from both the diagnostic and healing point of view. Among them, biocompatible and non-intrusive wearable monitoring devices, which are so flexible to adhere perfectly to biological tissue, and even to cells like neurons, gain increasing interest. However, fabricating the devices and the electrodes at nano/microscale remains a challenge. FluidFM is a force-controlled nanopipette, a versatile tool also for 2D patterning and 3D printing in liquid environment, opening the opportunity to manufacture the devices at the sub-micron scale. We are going to create the devices and electrodes depositing conductive polymers with the FluidFM and then to perform the opportune characterization.
Keywords
Conductive polymers, FluidFM, colloids, electrochemistry, nanoscale electrodes, characterization, biomedical monitoring, interdisciplinary
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Master Thesis
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Published since: 2024-05-03 , Earliest start: 2024-02-01 , Latest end: 2024-09-30
Organization Biosensors and Bioelectronics (LBB)
Hosts Xu Mengjia
Topics Medical and Health Sciences , Engineering and Technology , Physics
Characterization and investigating 2D skin disease model via biosensing and optical imaging
Pemphigus vulgaris (PV) is a unique group of autoimmune diseases. Researches have demonstrated that antibody-induced disruption of Dsg3 transadhesion initiates a signaling response in basal keratinocytes followed by loss of tissue integrity. The complexity of morphogenesis and tissue regeneration implies the existence of a transcellular communication network in which individual cells sense the environment and coordinate their biological activity in time and space. To understand the fascinating ability of tissue self-organization, comprehensive study of biophysical properties (cell topography and bioelectricity) in combination with the analysis of biochemical networks (signaling pathways and genetic circuits) is required. Together with the University of Bern and University of Lübeck, we aim to utilize the tools to study the topography and electrophysiology (cell potential, ion channel recording, localized ion detection, charges) of HPEK cells (human primary keratinocytes cells) to unravel the signaling pathways of the disease. We utilize optical imaging (fluorescence dyes) and biosensing tools (including the state of the art hs-SICM and electrical FluidFM setup) to study HPEK cells upon desmosome disruption.
Keywords
Disease, signaling pathways, 2D model, cell culture, biosensors, AFM, electrical, FluidFM, SICM, dyes, imaging, topography, electrophysiology, data analysis, interdisciplinary
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Semester Project , Lab Practice , Bachelor Thesis , Master Thesis , Summer School
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Published since: 2024-05-03
Organization Biosensors and Bioelectronics (LBB)
Hosts Xu Mengjia
Topics Medical and Health Sciences , Engineering and Technology , Chemistry , Biology
Assay development for cancer diagnostics
You will develop a diagnostic test for testicular cancer. The focus of the project will be on creating the biochemical protocols for the test. The project is in collaboration with a prelaunch startup and a hospital (USZ). Therefore, it is ideal for motivated students who want to have a direct impact
Keywords
diagnostic, diagnostics, test, biosensing, sensing, biosensor, sensor, dna, rna, mirna, cancer, functionalization, gold, nanoparticles, biochemistry, chemistry, assay, surface chemistry,
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Semester Project , Internship , Lab Practice , Bachelor Thesis , Master Thesis , Summer School
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Published since: 2024-04-10
Organization Biosensors and Bioelectronics (LBB)
Hosts Blickenstorfer Yves
Topics Engineering and Technology , Chemistry , Biology
Develop microfluidics for at-home blood testing
Collaborating with a dynamic startup, you will work on designing, manufacturing, and testing microfluidic devices to quantify biomolecules associated with chronic inflammation, heart attacks, and tropical diseases.
Keywords
Microfluidics, Fluidics, blood testing, diagnostics, biosensing, biosensor, diseases, healthcare, electrochemistry, Interdisciplinary, startup, impact, impactful, Laboratory of Biosensors and Bioelectronics, LBB, Quantification, Biomedical engineering, Materials science, Physics, Chemistry, Biochemistry, Biotechnology, Biology, Innovation
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Semester Project , Collaboration , Internship , Lab Practice , Bachelor Thesis , Master Thesis , Summer School
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Published since: 2024-04-10 , Earliest start: 2024-01-09
Organization Biosensors and Bioelectronics (LBB)
Hosts Blickenstorfer Yves
Topics Medical and Health Sciences , Engineering and Technology , Chemistry , Biology , Physics
Revolutionize at-home diagnostics
Join our interdisciplinary student project to transform at-home diagnostics! Work on cutting-edge technology, boost sensitivity, engineer tests for seamless home use, and develop targeted disease detection. Help us to shape the future of healthcare.
Keywords
diagnostics, assay, electrochemistry, biosensing, sensing, sensor, biosensor, disease, detection, interdisciplinary, electrochemical, microfluidics, impact, health, startup
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Semester Project , Lab Practice , Bachelor Thesis , Master Thesis , ETH Zurich (ETHZ) , Summer School
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Published since: 2024-04-10 , Earliest start: 2023-07-26
Organization Biosensors and Bioelectronics (LBB)
Hosts Blickenstorfer Yves
Topics Medical and Health Sciences , Engineering and Technology , Chemistry , Biology , Physics
Develop the electronics for a new medical sensor
You will work on bringing medical tests to peoples home. You will further develop the hardware and software for a readout device that can perform a variety of diagnostic tests in a reliable but simple fashion.
Keywords
Electronics, Software, Sensor, Biosensor, Potentiostat, Analog, Data Analysis, Noise Filtering, Start-up, printed circuit board, PCB, C++, Arduino, Microcontroller, Diagnostic, Medical
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Semester Project , Internship , Lab Practice , Bachelor Thesis , Master Thesis , Summer School
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Published since: 2024-04-10
Organization Biosensors and Bioelectronics (LBB)
Hosts Blickenstorfer Yves
Topics Engineering and Technology
Advancing Single-Molecule Sensing for Protein Sequencing
In this project, you will have the opportunity to contribute to the development and optimization of a single-molecule sensor designed for the detection, identification, and sequencing of important biomolecules such as DNA and proteins. The sensor technology is built upon the principles of microfluidics, nanofabrication, and machine-learning data analysis. It is an excellent fit for students who possess skills and a strong interest in these fields and are eager to engage in an interdisciplinary project with significant potential impact.
Keywords
nanopore sensing, single-molecule detection, protein sequencing, dna sequencing, nanotechnology, microfluidics, nanofabrication, machine learning, interdisciplinary, biomolecular analysis, data analysis
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Master Thesis
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Published since: 2024-03-19 , Earliest start: 2023-09-18 , Latest end: 2024-11-30
Organization Biosensors and Bioelectronics (LBB)
Hosts Hengsteler Julian
Topics Medical and Health Sciences , Engineering and Technology , Chemistry , Biology , Physics