Semenov, Oleg, Dr.

Fields of interests

• Regenerative medicine and reconstruction of human tissues using stem cells
• Creation of 3D complex human tissue models in vitro for drug screening
• Creation of stem cell based biocompatible implants for in vivo applications

Current projects

Stem Cell Sheet Engineering

• Stem cell sheet differentiation instructed by adjastment of end-differentiated cells
• Development of an 3D in vitro tissue models from single cell sheets for drug screening applications
• Development of 3D stem and adult cell sheet structures for prospective transplantation

Stem Cells from Human Obstetrical Sources

• Establishment of critical parameters for isolation, characterization, and long-term cultivation of multipotent stem cells from human fetal tissues
• Validation of human fetal tissue-isolated multipotent stem cells for prospective clinical applications

CRYSTAL

• Cryobanking of stem cells for human therapeutic applications

List of Publications

• Semenov O.V., Malek A., Bittermann A-G., Voros J., Zisch A.H., Polyelectrolyte Multilayer Substrates for Adhesion, Expansion, and Differentiation of Human Mesenchymal Stem Cells; Tissue Engineering Part A 2009 Oct; 15(10): 2977 – 90.
• Semenov O.V., Koestenbauer S., Riegel M., Zech N., Zisch A.H., Malek A., Multipotent Mesenchymal Stem Cells from Human Placenta. Critical Parameters for Isolation and Maintenance of Stemness after Isolation; American Journal of Obstetrics and Gynecology 2010 Feb; 202(2): 193.e1 - 193.e13.
• Guillaume-Gentil O., Semenov O., Roca A.S., Groth T., Zahn R., Vörös J., Zenobi-Wong M., Engineering the Extracellular Environment: Strategies for Building 2D and 3D Cellular Structures; Advanced Materials 2010 Sep. 14.

Oral Presentations

• Stem Cell Sheet Engineering. Tissue Engineering and Regenerative Medicine International Society (TERMIS) Asian-Pacific, Tokyo, Japan (2007).
• Stem Cell Sheet Engineering. 7th Day of Clinical Research, University Hospital Zurich, Zurich, Switzerland (2008).
• Stem Cell Sheet Engineering on Polyelectrolyte Multilayer Films. Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Union, Porto, Portugal (2008).
• Multipotent Mesenchymal Stem Cells from Human Placenta: Critical Parameters for Isolation and Maintanance of Stemness after Isolation. Annual Meeting of Society of Maternal-Fetal Medicine (SMFM), San Diego, CA, USA (2009).
• Conductive Surfaces for Stem Cell Sheet Engineering. Annual Meeting of Swiss Society for Biomaterials (SSB), Dübendorf, ZH, Switzerland (2010)
• Conductive Substrates for Stem Cell Sheet Engineering. Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Union, Galway, Ireland (2010)

Poster Presentations

• Cell sheets on polyelectrolyte multilayer films for construction of in vitro tissue models. CCMX Annual Meeting, Fribourg, Switzerland (2007).
• Engineering and Differentiation of Stem Cell Sheets. Biosurf, Zurich, Switzerland (2007).
• Human Placenta-Derived Stem Cells for Prospective Use in Cell Sheet Engineering. 4th SSCN Annual Meeting, Zurich, Switzerland (2007).
• Human Stem Cell Sheet Engineering. CCMX Annual Meeting, Bern, Switzerland (2008).
• Stem Cell Sheet Engineering on Polyelectrolyte Multilayer Films. 8th World Biomaterials Congress, Amsterdam, The Netherlands (2008).
• Polyelectrolyte Multilayer Substrates for Adhesion and Differentiation of Human Stem Cells. 8th Day of Clinical Research, University Hospital Zurich, Zurich, Switzerland (2009).
• PEM Substrates for Stem Cell Sheet Engineering. CCMX Annual Meeting, Bern, Switzerland (2009).
• Human Stem Cell Sheets Engineered on PEM Coatings for Prospective Transplantation. 5th ZHIP Symposium, Zurich, Switzerland (2009).
• Polyelectrolyte Multilayer Substrates for Adhesion and Differentiation of Stem Cells. 22nd European Conference on Biomaterials, Lausanne, Switzerland (2009).
• Stem Cell Sheet Engineering on Conductive Surfaces. 9th Day of Clinical Research, University Hospital Zurich, Zurich, Switzerland (2010).
• Cell Sheet Engineering - New Way for Prospective Human Stem Cell Transplantation 3th International Nano Bio Conference, ETH-Zurich, Zurich, Switzerland (2010)

Awards

• 50 Best Submitted Abstracts. Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Union, Porto, Portugal (2008).
• Best Poster Presentation. 9th Day of Clinical Research, University Hospital Zurich, Zurich, Switzerland (2010).
• 50 Best Submitted Abstracts. Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Union, Galway, Ireland (2010).

Memberships

• Tissue Engineering and Regenerative Medicine International Society (TERMIS)
• European Society for Biomaterials (ESB)
• Swiss Stem Cell Network (SSCN)